The use of intraarticular forms of hyaluronic acid in degenerative dystrophic and post-traumatic lesions of the joints is a well-studied method with an established safety profile, which has been used for several decades.
In extremely rare cases, the manifestation of local transient inflammatory symptoms (pain, fever, redness and swelling, exudate increment in the joint cavity) are possible. After an intraarticular injection, reversible local reactions may occur, such as short-term restriction of mobility (stiffness), discomfort or heaviness in the joint, hematomas. The local application of ice for 5-10 minutes may reduce these effects.
There are reports of isolated cases of allergic reactions (e.g., itching, rash, urticaria) and anaphylactic reactions, septic arthritis, interstitial hemorrhages or hemorrhages in the joint cavity, tendenitis, phlebitis, paresthesia, dizziness, headaches, muscle spasms, fever, general malaise, peripheral edema after intra-articular injections of hyaluronic acid solutions.
If local or general symptoms appear, consult a physician.
In the case of severe reactions, the removal of an implant from the joint cavity can be recommended, including lavage in accordance with the current clinical guidelines.
If the reaction to the implant was not associated with the individual intolerance to the components of the product, it is possible to inject the implant in 3 weeks after an inflammation subsides.
FLEXOTRON® line implants successfully passed preclinical tests and confirmed their compatibility with biological tissues, cells and body fluids with which they come in contact in an implantable state. Disinfectants containing quaternary ammonium salts should not be used, since hyaluronic acid precipitates in the presence of these substances.
The information about incompatibility with other drugs, substances and intra-articular injected products is currently not available, however, a medical specialist should carefully read the relevant information in instructions for these drugs/substance/products and use with caution.
Exclusively practicing medical professionals
The product application should be carried out in aseptic conditions of procedural and manipulation rooms by medical personnel who are familiar with the technique of intra-articular injections.
The volume of one implant was designed to be similar to the safe volume of adult knee cavity. There are no restrictions for anthropometric and anatomical features of a target patient.