The impact of various drugs and some MD on the human body is a complicated and ambiguous process. "Old" drugs often surprise us with new applications. Even before the appearance of any medicines, herbalists actively used willow bark against fever. In the 19th century, the glycoside salicin was isolated from it and the salicylic acid and sodium salicylate molecules were obtained. In 1899, an effective and quick-acting drug of aspirin appeared, which quickly relieved high fever and pain syndrome in rheumatism and other diseases. Later this substance has been proven to be able to irreversibly inhibit the activity of platelets, and in the second half of the 20th century another indication for the use of acetylsalicylic acid was defined for primary and secondary prevention of various vascular accidents (heart attack, stroke).

Another bright example is the drug Viagra (sildenafil citrate), which in 1992 was invented by Pfizer Pharmaceutical Company in search of a new remedy for the prevention and treatment of angina pectoris. Less known examples. A new indication for ibuprofen is a patent arterial duct. Thalilomide, which initially proved ineffective as an anti-seizure medication, is now finding its way into the treatment of leprosy, multiple myeloma and various malignancies. Phenobarbital is now prescribed for some diseases related to bilirubin metabolism (Gilbert's disease and Crigler-Najjar syndrome). The good news is that scientists and medical professionals continue to find numerous new effects and applications for already well-known medications. Update Orthopaedics certainly supports these initiatives, which is reflected in numerous materials of this issue.
Issue 42
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