PLINEST® is a viscoelastic, non-pyrogenic,sterile polynucleotide gel forsingle use, for intradermal infiltration. Polynucleotides are substence of natural origin thet are extracted from fish. They are highly purified and re-absorbable. In addition to their moisturising properties, they have a trophic effect on fibroblasts. This makes them useful for improving the suppleness and tonicity of the skin.

Skin proliferation
Polynucleotide compounds cause synergy with growth factors and act directly on the purinergic receptor (Adenosine A2a), inducing a proliferative response.
Anti-inflammatory effect
PDRN (polydeoxyribonucleotides) promote the production of anti-inflammatory interleukins (IL-10), and reduce the activity of pro-inflammatory ones (TNF α, HMGB-1, IL-6).

Thickening of the dermis
Increased tone, turgor and elasticity
Normalization of hydrobalance
Restoration of the lipid layer
Even out skin tone.

Mature, atonic skin.​​
Pronounced age-related changes, wrinkles and folds, stretch marks, stretch marks.

Prevention of aging for all morphotypes of aging;
senile skin atrophy;
wrinkles around the eyes;
deep creases and wrinkles in the perioral area;
gravitational ptosis (I, II degree);
involutional changes in the skin of the lower third of the face;
flabby atonic neck;
pigmentation;
post-acne, atrophic scars, stretch marks;
preparation for facial rejuvenation using radical methods.

Reducing the depth of wrinkles;
Narrowing of pores, leveling of relief;
Improved skin texture;
Slowing down aging

Keep out of the reach of children. Do not use the drug if the packaging is damaged. Do not use the drug after the expiration date indicated on the package. The expiration date refers to the unopened product and implies compliance with the correct storage conditions. Do not mix PLINEST® with other drugs. Use the drug immediately after opening the package. Any leftovers should be discarded.
Disposable product, do not re-sterilize. Do not release into the environment after use. Disposal should be in accordance with generally accepted medical practice and applicable regulations. The administration of PLINEST® may only be carried out by specialists authorized to do so in accordance with local legislation.
Service life or shelf life - 36 months.

Mastelli srl, Via Bussana Vecchia 32, 18038 Sanremo (IM) - Italy - www.mastelli.it