Polynucleotide compounds cause synergy with growth factors and act directly on the purinergic receptor (Adenosine A2a), inducing a proliferative response.
PDRN (polydeoxyribonucleotides) promote the production of anti-inflammatory interleukins (IL-10), and reduce the activity of pro-inflammatory ones (TNF α, HMGB-1, IL-6).
As a result:
regeneration of the epidermis,
increase in the thickness of granulation tissue,
filling the extracellular matrix with both collagen and non-collagen components.